Evidence supporting the use of: Vitamin B3 (various)
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B3, also known as niacin or nicotinamide, has some scientific evidence supporting its use in migraine management, but the data are limited and not robust. A few small clinical studies and case reports, primarily from the mid-20th century, suggested that niacin could help abort or prevent migraine attacks, possibly due to its vasodilatory effects or its role in improving cerebral blood flow. For example, a 1947 case series by Dr. Abram Hoffer described some migraine patients experiencing relief with niacin; however, these were not controlled trials. More recent literature reviews and clinical guidelines generally do not recommend vitamin B3 as a first-line migraine therapy due to insufficient high-quality evidence. Most contemporary research focuses on other B vitamins such as riboflavin (B2), which has more substantial evidence for migraine prevention. Overall, while there is a plausible biological rationale and some anecdotal and preliminary scientific support, high-quality randomized controlled trials are lacking. Therefore, its use for migraine is considered to have limited scientific validation, and it is not widely endorsed in clinical practice guidelines.

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