Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B2, also known as riboflavin, has scientific evidence supporting its use in the prevention of migraines. Multiple randomized controlled trials (RCTs) and meta-analyses have demonstrated that high-dose riboflavin supplementation (typically 400 mg daily) can reduce the frequency and duration of migraine attacks in adults. The proposed mechanism is based on riboflavin’s role as a precursor for flavoproteins involved in mitochondrial energy production. Since impaired mitochondrial function is believed to contribute to migraine pathophysiology, enhancing mitochondrial efficiency with riboflavin may mitigate this trigger.

Key studies include a 1998 double-blind RCT by Schoenen et al., which found a significant reduction in migraine frequency compared to placebo after three months of 400 mg/day riboflavin. Subsequent studies and systematic reviews (e.g., a 2017 review in Journal of Clinical Pharmacy and Therapeutics) have largely supported these findings, though some variability exists in study size and outcomes. Riboflavin is well-tolerated, with minimal side effects, making it a reasonable option for migraine prophylaxis, especially in patients seeking non-pharmacologic interventions.

While riboflavin is not universally effective for all individuals with migraine, and evidence in pediatric populations is less robust, its scientific validation and favorable safety profile justify its use as a preventive strategy for migraines.

More about Vitamin B2 (various)
More about Migraine

Other ingredients used for Migraine

Other health conditions supported by Vitamin B2 (various)

Products containing Vitamin B2 (various)