Evidence supporting the use of: Vitamin B2 (mixed)
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B2, also known as riboflavin, has scientific support for its use in migraine prevention. Several clinical studies, including randomized controlled trials, have investigated riboflavin supplementation for reducing migraine frequency and severity. The proposed mechanism involves riboflavin’s role in mitochondrial energy production; migraine sufferers may have underlying mitochondrial dysfunction, and riboflavin is a key cofactor in mitochondrial metabolism. A pivotal double-blind, placebo-controlled study published in Neurology (1998) found that 400 mg/day of riboflavin significantly reduced migraine attack frequency compared to placebo. Subsequent meta-analyses and systematic reviews have generally supported these findings, though the magnitude of effect can be modest and evidence quality varies. Riboflavin is well-tolerated with minimal side effects, making it a low-risk option for migraine prophylaxis. Major headache societies, including the American Headache Society and the European Federation of Neurological Societies, include riboflavin among non-pharmacologic preventive treatments for migraine. However, not all studies have found benefit, and some methodological limitations exist in the literature. Overall, riboflavin’s role is supported by moderate-quality evidence and is recognized in clinical guidelines, particularly for adults and, with less evidence, in children and adolescents.

More about Vitamin B2 (mixed)
More about Migraine

Other health conditions supported by Vitamin B2 (mixed)

Anemia
Migraine
Seborrhea
Skin Care (general)

Products containing Vitamin B2 (mixed)

We currently have no products on Caring Sunshine that contain this ingredient.