Evidence supporting the use of: Phthalide
For the health condition: Migraine

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Phthalide compounds, particularly those found in certain traditional Chinese medicinal plants such as Ligusticum chuanxiong (Chuanxiong) and Angelica sinensis, have been used for centuries in East Asian medicine for the management of headaches, including migraines. The use of these plants, and by extension their phthalide constituents (such as ligustilide), is primarily rooted in traditional practice rather than being strongly validated by modern clinical research. Traditional Chinese Medicine (TCM) texts describe these herbs as effective for promoting blood circulation and alleviating pain, with migraine relief being a common indication.

Scientific studies exploring the effects of phthalides on migraine are limited, mostly consisting of preclinical research. Some animal and in vitro studies suggest that phthalides may have vasodilatory, anti-inflammatory, and neuroprotective properties that could theoretically benefit migraine sufferers. However, high-quality clinical trials in humans are lacking, and systematic reviews note insufficient evidence to confirm efficacy or safety for this indication. Therefore, while the use of phthalide-containing herbs for migraine is clearly established in tradition, current scientific evidence is limited and does not robustly support their effectiveness.

More about Phthalide
More about Migraine

Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaenoic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
Melatonin
Moringa
Niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
Valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
Zinc
atractylodes
blackboard tree
Swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
apple cider vinegar
Albizia
alpha-lipoic acid
atractylone
betony
black seed
Baikal Skullcap
beta-hydroxybutyrate
Blepharis
balsam
banyan
brahmi
butterbur
Bifidobacteria
Black Hellebore
Chinese silkvine
crocin
creatine
cannabidiol
Corydalis
Carthamus
cola nut
docosahexaenoic Acid
danshen
eicosapentaenoic acid
folic acid
flavin mononucleotide
Ficus religiosa
fish
flavanones
Ficus simplicissima
frankincense
goldthread
Gelsemium
ginkgolides
Ginkgoside
Hellebore
iridoids
ketone salts
kuding tea
lemon balm
Lesser speargrass
little ironweed
linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone

Products containing Phthalide

We currently have no products on Caring Sunshine that contain this ingredient.