Evidence supporting the use of: Omega-3
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Omega-3 fatty acids have been investigated for their potential role in migraine prevention and management, with some scientific evidence suggesting modest benefit. Omega-3s, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), possess anti-inflammatory properties, which is relevant as inflammation is thought to contribute to migraine pathophysiology. Several small randomized controlled trials and observational studies have reported reductions in migraine frequency or severity with omega-3 supplementation, though results are mixed and often limited by small sample sizes, short durations, and varying dosages.

A 2018 systematic review found that while some studies suggested a potential reduction in migraine attacks with omega-3 supplementation, the overall quality of evidence was low and did not allow for definitive conclusions. More recent trials have shown that diets enriched with omega-3s (and reduced in omega-6s) may decrease headache frequency and intensity, but these effects are generally described as modest. Current clinical guidelines do not recommend omega-3s as a first-line treatment for migraine, but they may be considered as adjunctive therapy, especially given their favorable safety profile.

In summary, scientific evidence for omega-3 in migraine is emerging but not robust; while some benefit has been observed, larger and more rigorous studies are needed to confirm efficacy. Use of omega-3s is scientifically motivated due to their anti-inflammatory effects, but the strength of clinical evidence remains low to moderate.

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Products containing Omega-3

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