Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Luteolin, a flavonoid found in various plants such as celery, parsley, and chamomile, has garnered scientific interest for its potential role in migraine management. The rationale behind its use is primarily based on its anti-inflammatory, antioxidant, and neuroprotective properties. Preclinical research indicates that luteolin can inhibit the release of pro-inflammatory cytokines and modulate the activity of mast cells, both of which have been implicated in the pathophysiology of migraines. Additionally, luteolin has been shown to inhibit the activation of microglia and reduce oxidative stress in neuronal tissues, mechanisms that are thought to contribute to migraine onset and progression.

However, while animal studies and in vitro experiments provide plausible biological mechanisms, direct clinical evidence in humans remains limited. Most of the supportive data come from laboratory or animal models, with only a few small pilot clinical trials or case reports exploring luteolin, sometimes in combination with other compounds (such as quercetin or palmitoylethanolamide). These early studies suggest potential benefit in reducing migraine frequency or severity, but they are insufficient to draw firm conclusions regarding efficacy. Therefore, while the scientific rationale exists and initial findings are promising, large-scale, well-controlled clinical trials are lacking.

In summary, luteolin’s use for migraine is supported by scientific rationale and modest preclinical evidence, but robust clinical validation is currently insufficient, justifying a rating of 2 out of 5.

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