Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ketone salts have recently been investigated for their potential role in migraine management, based on emerging scientific evidence rather than long-standing traditional use. Migraine has been linked to metabolic dysfunction and impaired brain energy metabolism. The ketogenic diet, which elevates blood ketone levels, has shown some efficacy in reducing migraine frequency and severity in preliminary studies. Ketone salts are supplements that provide exogenous ketones (usually beta-hydroxybutyrate) and can raise blood ketone levels without requiring strict dietary changes.

Small pilot studies and case reports suggest that exogenous ketones may help reduce migraine frequency and improve symptoms, possibly by providing an alternative energy source for neurons, reducing neuroinflammation, or modulating neurotransmitter systems. For example, a 2020 pilot study (Di Lorenzo et al.) found that exogenous ketone supplementation reduced migraine days in a group of patients. However, the total number of participants in such studies is small, and research is still at an early stage. No large-scale, high-quality randomized controlled trials have yet confirmed the efficacy of ketone salts for migraine, and the optimal dosing and long-term safety remain uncertain.

In summary, the use of ketone salts for migraine is grounded in recent scientific hypotheses and early clinical evidence, but the overall quality and quantity of evidence is currently low, justifying a rating of 2 out of 5.

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