Evidence supporting the use of: Ginkgolide A
For the health condition: Migraine

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ginkgolide A is a terpene lactone found in the leaves of the Ginkgo biloba tree. Its use in migraine is supported primarily by modest scientific evidence rather than longstanding traditional use. Several clinical studies, particularly in Europe, have investigated standardized Ginkgo biloba extracts containing ginkgolide A (as well as ginkgolide B and bilobalide) for migraine prophylaxis, often in combination with other compounds such as coenzyme Q10 and magnesium. Ginkgolide A is believed to exert its effects partly by antagonizing platelet-activating factor (PAF), which plays a role in neuroinflammation and vasodilation linked to migraine pathophysiology. Some small-scale randomized controlled trials and open-label studies have reported a reduction in migraine attack frequency and duration following administration of ginkgolide-containing preparations. However, these studies are generally limited by small sample sizes, short durations, and often use combination formulas, making it difficult to attribute effects solely to ginkgolide A. Meta-analyses and systematic reviews acknowledge the potential of Ginkgo biloba extracts in migraine management but consistently call for larger, better-designed trials to clarify efficacy and safety. In summary, while there is some scientific rationale and preliminary clinical evidence for the use of ginkgolide A in migraine prophylaxis, the overall strength of evidence is moderate to low (rated 2/5).

More about Ginkgolide A
More about Migraine

Products containing Ginkgolide A

We currently have no products on Caring Sunshine that contain this ingredient.