Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Folic acid has been investigated for its potential role in migraine management, particularly for migraine with aura. The rationale is based on studies that suggest a subset of migraine sufferers have elevated homocysteine levels, which may be influenced by genetic polymorphisms (such as MTHFR mutations) affecting folate metabolism. Folic acid, often combined with vitamins B6 and B12, can lower homocysteine levels. A few small randomized controlled trials, including a notable study published in Pharmacogenetics and Genomics (2015), have shown that supplementation with folic acid, B6, and B12 reduced migraine frequency and severity in some patients, especially those with specific MTHFR gene variants. However, results are inconsistent, and other studies have failed to show significant benefit. Systematic reviews and guidelines do not currently recommend folic acid alone as a standard migraine treatment due to limited and mixed evidence. Thus, while there is some scientific basis—particularly for individuals with elevated homocysteine or MTHFR mutations—the overall evidence supporting folic acid for migraine prevention or treatment is modest and not universally accepted. More large-scale, high-quality trials are needed to clarify its efficacy and identify which subgroups, if any, may benefit.

More about Folic Acid
More about Migraine

Other ingredients used for Migraine

Other health conditions supported by Folic Acid

Products containing Folic Acid