Evidence supporting the use of: Flavanones (various)
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavanones are a class of flavonoids commonly found in citrus fruits such as oranges, lemons, and grapefruits. There is emerging scientific interest in the potential role of flavanones in migraine management, primarily due to their antioxidant, anti-inflammatory, and vasomodulatory properties. Several laboratory and animal studies suggest that flavanones can modulate neuroinflammatory pathways and oxidative stress, factors implicated in migraine pathophysiology. In particular, hesperidin and naringenin—two well-studied flavanones—have demonstrated the ability to reduce inflammation and oxidative damage in neural tissues in preclinical models.

However, direct evidence from human clinical trials remains limited. A handful of small-scale studies and reviews propose that flavanone-rich diets may help reduce migraine frequency and intensity, but results are preliminary. For example, a 2021 review in Frontiers in Nutrition highlighted the neuroprotective effects of citrus flavanones but emphasized the need for larger, well-controlled trials to establish clear efficacy and dosing guidelines for migraine patients. Currently, flavanones are not a standard or widely endorsed therapy for migraines, but their use is supported by plausible biological mechanisms and early-stage research. Thus, while there is some scientific rationale, the evidence base is weak, and further research is needed.

More about Flavanones (various)
More about Migraine

Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaenoic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
Melatonin
Moringa
Niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
Valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
Zinc
atractylodes
blackboard tree
Swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
apple cider vinegar
Albizia
alpha-lipoic acid
atractylone
betony
black seed
Baikal Skullcap
beta-hydroxybutyrate
Blepharis
balsam
banyan
brahmi
butterbur
Bifidobacteria
Black Hellebore
Chinese silkvine
crocin
creatine
cannabidiol
Corydalis
Carthamus
cola nut
docosahexaenoic Acid
danshen
eicosapentaenoic acid
folic acid
flavin mononucleotide
Ficus religiosa
fish
flavanones
Ficus simplicissima
frankincense
goldthread
Gelsemium
ginkgolides
Ginkgoside
Hellebore
iridoids
ketone salts
kuding tea
lemon balm
Lesser speargrass
little ironweed
linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone

Products containing Flavanones (various)

We currently have no products on Caring Sunshine that contain this ingredient.