Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavanones are a class of flavonoids commonly found in citrus fruits such as oranges, lemons, and grapefruits. There is emerging scientific interest in the potential role of flavanones in migraine management, primarily due to their antioxidant, anti-inflammatory, and vasomodulatory properties. Several laboratory and animal studies suggest that flavanones can modulate neuroinflammatory pathways and oxidative stress, factors implicated in migraine pathophysiology. In particular, hesperidin and naringenin—two well-studied flavanones—have demonstrated the ability to reduce inflammation and oxidative damage in neural tissues in preclinical models.

However, direct evidence from human clinical trials remains limited. A handful of small-scale studies and reviews propose that flavanone-rich diets may help reduce migraine frequency and intensity, but results are preliminary. For example, a 2021 review in Frontiers in Nutrition highlighted the neuroprotective effects of citrus flavanones but emphasized the need for larger, well-controlled trials to establish clear efficacy and dosing guidelines for migraine patients. Currently, flavanones are not a standard or widely endorsed therapy for migraines, but their use is supported by plausible biological mechanisms and early-stage research. Thus, while there is some scientific rationale, the evidence base is weak, and further research is needed.

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