Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavanones are a subclass of flavonoids commonly found in citrus fruits such as oranges, lemons, and grapefruits. Their potential use in migraine management is primarily supported by emerging scientific research rather than longstanding traditional use. Some studies suggest flavanones possess antioxidant and anti-inflammatory properties, which may help reduce neurogenic inflammation and oxidative stress—both implicated in migraine pathophysiology. For example, hesperidin and naringenin, two prominent flavanones, have demonstrated efficacy in animal models by reducing the frequency and severity of migraine-like symptoms, possibly through modulation of the trigeminovascular system and inhibition of pro-inflammatory cytokines. However, robust clinical data in humans are limited, and most evidence is preclinical or based on small pilot studies. There is not yet sufficient large-scale clinical trial data to firmly recommend flavanones as a primary treatment for migraines, but the mechanistic rationale and early findings provide grounds for further research. In summary, while scientific evidence exists, it remains preliminary and does not currently support widespread clinical use.

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