Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Cornelian Cherry (Cornus mas) has a long history of use in traditional medicine systems, especially in Eastern Europe and parts of Asia, for a variety of ailments, including gastrointestinal issues, fever, and inflammation. Its use for migraine relief, however, is not extensively documented in authoritative ethnobotanical sources. Where connections exist, they are often indirect, based on the fruit’s general anti-inflammatory and antioxidant properties, which are believed in folk medicine to help with "head pain" or "headaches," occasionally encompassing migraines within that broader category. There is no robust clinical or scientific evidence directly supporting Cornelian Cherry for migraine treatment or management. Preclinical studies have identified antioxidant compounds such as anthocyanins and flavonoids in the fruit, which could theoretically play a role in reducing neuroinflammation—a component in migraine pathophysiology—but these findings have not been translated to human clinical trials or migraine-specific studies. Thus, while some traditional uses for general headache exist, the evidence is scant and not migraine-specific, and its use for migraine is best described as traditional with weak support.

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