Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Coenzyme Q10 (CoQ10) is supported by scientific evidence for the prevention and treatment of migraine. Several clinical studies have investigated its effectiveness, focusing on its role in mitochondrial function and oxidative stress, factors thought to contribute to migraine pathophysiology. A notable randomized controlled trial published in Neurology (2005) demonstrated that daily supplementation with 100 mg of CoQ10 three times a day significantly reduced migraine attack frequency, headache days, and days with nausea compared to placebo. Other meta-analyses and systematic reviews have found that CoQ10 supplementation (typically 100-400 mg/day) is associated with a reduction in migraine frequency and severity, particularly among adult sufferers.

CoQ10 is believed to aid in migraine prevention by improving mitochondrial energy metabolism, as mitochondrial dysfunction has been implicated in migraine pathogenesis. It also exhibits antioxidant properties, which may help reduce neuroinflammation and oxidative stress linked to migraine attacks. The American Academy of Neurology and the American Headache Society recognize CoQ10 as "probably effective" for migraine prevention, especially in individuals seeking alternative or adjunctive therapies.

While CoQ10 is generally well-tolerated and considered safe, the magnitude of benefit is moderate, and not all patients respond. More large-scale, high-quality studies are needed to confirm optimal dosing and long-term efficacy. Nonetheless, current evidence supports the use of CoQ10 as a reasonable option for migraine prophylaxis, particularly for those who prefer non-pharmacological interventions.

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