Evidence supporting the use of: Atractylone
For the health condition: Migraine

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Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Atractylone is a sesquiterpene compound found in Atractylodes species, especially Atractylodes macrocephala, a traditional Chinese medicinal herb. Historically, Atractylodes rhizome has been used in Traditional Chinese Medicine (TCM) for a variety of ailments, including digestive disorders and as a tonic, but only occasionally is it mentioned in relation to headaches or migraine-like symptoms. In such cases, its use is generally part of multi-herb formulas, where it is thought to "tonify the spleen" and "dispel dampness," concepts unique to TCM theory rather than modern biomedical understanding. There is no robust clinical or preclinical scientific evidence directly supporting atractylone or Atractylodes extracts for migraine prevention or treatment. Some animal and in vitro studies suggest atractylone possesses anti-inflammatory and neuroprotective properties, but these have not been specifically linked to migraine models or human trials. Thus, while there is some traditional precedent—though not strong or migraine-specific—the evidence is minimal and not validated by contemporary biomedical research.

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