Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha lipoic acid (ALA) is an antioxidant that has garnered some scientific interest for its potential in migraine prevention. The rationale for its use is primarily based on its antioxidant properties and its role in mitochondrial function, as mitochondrial dysfunction and oxidative stress have both been implicated in the pathophysiology of migraine. Several small-scale clinical studies have been conducted to investigate its efficacy. For example, a 2007 randomized, double-blind, placebo-controlled pilot study by Magis et al. found that ALA supplementation (600 mg/day for 3 months) led to a reduction in headache frequency and disability scores compared to placebo. Another 2016 study by Sensen et al. also reported positive effects on migraine frequency and severity. However, these studies are limited by small sample sizes and short durations.

Systematic reviews of nutraceuticals for migraine prevention often mention ALA as a promising adjunct, but emphasize the need for larger, high-quality trials to establish its effectiveness. ALA is not considered a first-line therapy, and its use is generally reserved for patients interested in complementary approaches or those intolerant to standard therapies. The overall evidence supporting alpha lipoic acid for migraine prevention is suggestive, but not robust. Therefore, while there is scientific interest and some preliminary validation, the strength of evidence is modest, warranting a rating of 2 out of 5.

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Products containing alpha lipoic acid

Nature's Sunshine Alpha Lipoic Acid
Nature's Sunshine Brain Protex (With Huperzine A)
Nature's Sunshine Cellular Energy
Nature's Sunshine Heavy Metal Detox
Nature's Sunshine Super Antioxidant
Nature's Sunshine VitaWave