Evidence supporting the use of: Vitamin D
For the health condition: Metabolic Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D has been investigated for its potential role in metabolic syndrome, a cluster of conditions that increase the risk of heart disease, stroke, and type 2 diabetes. Epidemiological studies have observed an association between low serum vitamin D levels and increased prevalence of metabolic syndrome and its components, such as insulin resistance, hypertension, dyslipidemia, and abdominal obesity. Mechanistically, vitamin D is thought to influence glucose metabolism and insulin sensitivity through its effects on pancreatic β-cell function and inflammation modulation.

However, while observational studies suggest a link, randomized controlled trials (RCTs) and meta-analyses provide more modest support. Some interventional studies have shown small improvements in insulin sensitivity or lipid profiles with vitamin D supplementation in deficient individuals, but the results are inconsistent. A 2017 meta-analysis published in Obesity Reviews reported a modest reduction in fasting glucose but no significant effect on other metabolic syndrome parameters. More recent reviews and large RCTs, such as the VITAL trial, have not found convincing evidence that vitamin D supplementation prevents or treats metabolic syndrome in the general population.

Overall, while there is a plausible biological rationale and some early evidence, the current weight of scientific evidence does not robustly support vitamin D supplementation as a treatment for metabolic syndrome unless deficiency is present. Ongoing research may clarify its role, particularly in populations with low baseline vitamin D levels.

More about vitamin D
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Other ingredients used for Metabolic Syndrome

7-hydroxymatairesinol (HMR)
7-Keto-DHEA
acai berry
akkermansia muciniphila
algal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anchovies
anthocyanins
asparagus
bacillus subtilis
banaba
barley
berberine
Beta-Glucan
beta-sitosterol
bifidobacterium longum
bitter melon
black garlic
blueberry
brussel sprouts
butyrate triglyceride
campesterol
camu camu
canola oil
caterpillar mushroom
chia seed
chokeberry
chromium
cinnamon
conjugated linoleic acid (CLA)
turmeric
curcumin
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
flaxseed
fructooligosaccharides (FOS)
ginger
glucomannan
guar gum
hydroxycitric acid
inulin
krill oil
l-carnitine
lactobacillus helveticus
licorice root
mackerel
maitake mushroom
maqui berry
matcha
medium chain triglycerides (MCT)
moringa
naringin
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-7 fatty acids
omega-9 fatty acids
oyster mushroom
palmitoleic acid
quinoa
red yeast rice
reishi mushroom
resveratrol
rye
sardines
spirulina
tocotrienols
trans-pterostilbene
Urolithin A
vanadium
vanadyl sulfate
vitamin C
vitamin D
wheat grass
whey protein
xylooligosaccharides
zinc
β-nicotinamide mononucleotide (NMN)
algae
kidney beans
AMP-activated protein kinase (AMPK)
1-deoxynojirimycin
15,16-Dihydrotanshinone I
12-methylcarnosic acid
3-desoxy-7-KETO-DHEA
4-hydroxyisoleucine
5,7-Dimethoxyflavone
6-Paradol
Alpha Glucans
Ankaflavin
Apigenin
Aronia melanocarpa
Antrodia camphorata
Auricularia
Antirrhinin
Avocado
Ascophyllum nodosum
Acacetin
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Ampelopsin
Alpha phytosterol
Algal protein
Arabinoxylan
alpha Methyl Tetradecylthioacetic Acid
Arjunolic acid
Bifidobacterium adolescentis
Beta-hydroxybutyrate
Blakeslea trispora
Bean
Betanin
Brazil nut
Charantin
California chia
Cardarine
Cyanobacteria
Capsinoids
Cyanidin
chlorogenic acid
Capsiate
Chitin-Glucan Complex
Calanus finmarchicus
Crocetin
Cynaropicrin
Cystoseira canariensis
corosolic acid
Crypthecodinium
Carnosic acid
Docosahexaenoic Acid
Dunaliella
Dihydrocapsiate
Dragon Fruit
Dihydrolipoic Acid
D-Pinitol
Diosgenin
Ergothioneine
Ecklonia
peanut
Pistachio

Other health conditions supported by vitamin D

Acne
Allergies (food)
Allergies (respiratory)
Alzheimer's Disease
Amenorrhea
Anemia
Anorexia
Apathy
Arrhythmia
Arteriosclerosis
Arthritis
Asthma
Autism
Autoimmune Disorders
Backache
Birth Defects (prevention)
Body Building
Broken Bones
Calcium Deficiency
Cancer (natural therapy for)
Cancer (prevention)
Cancer Treatment (reducing side effects)
Cardiovascular Disease
Celiac Disease
Chronic Obstructive Pulmonary Disorder
Colds (antiviral)
Colds (general)
Colds (prevention)
Colds (with fever)
Concentration (poor)
Concussions
Confusion
Congestive Heart Failure
Contagious Diseases
Convalescence
Convulsions
Cramps (menstrual)
Cramps and Spasms
Crohn's Disease
Cystic Breast Disease
Cystic Fibrosis
Dandruff
Debility
Dementia
Depression
Dermatitis
Diabetes
Diabetic Retinopathy
Erectile Dysfunction
Estrogen (low)
Fatigue
Fibroids (uterine)
Fibromyalgia Syndrome
Fibrosis
Grave's Disease
Grief and Sadness
Hair (loss or thinning)
Hair Care (general)
Hashimoto's Disease
Headache (cluster)
Heart (weakness)
Hypertension
Hypothyroid
Infection
Infection (bacterial)
Infection (viral)
Infertility
Inflammation
Inflammatory Bowel Disorders
Influenza
Injuries
Irritable Bowel Syndrome
Itching
Knees (weak)
Leaky Gut Syndrome
Leprosy
Lesions
Leukemia
Lou Gehrig's Disease
Lupus
Lymphoma
Melanoma
Memory and Brain Function
Menopause
Menstrual Irregularity
Mental Illness
Metabolic Syndrome
Migraine
Miscarriage (prevention)
Mood Swings
Multiple Sclerosis
Muscle Tone (lack of)
Muscular Dystrophy
Myasthenia Gravis
Nephritis
Nerve Damage
Nervous Exhaustion
Numbness
Nursing
Obsessive Compulsive Disorder
Oral Surgery
Osteoporosis
Pain (general remedies for)
Pancreatitis
Paralysis
Parkinson's Disease
Peripheral Neuropathy
PMS (general)
PMS Type D
PMS Type H
PMS Type P
PMS Type S
Pneumonia
Polyps
Post Partum Depression
Post Partum Weakness
Pregnancy (herbs and supplements for)
Progesterone (low)
Prostatitis
Psoriasis
Rheumatoid Arthritis
Schizophrenia
Sciatica
Seasonal Affective Disorder
Senility
Tuberculosis