Evidence supporting the use of: Pterolstilbene
For the health condition: Metabolic Syndrome
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Pterostilbene is a naturally occurring polyphenol structurally related to resveratrol, found in blueberries and Pterocarpus marsupium. Its use for metabolic syndrome is based primarily on preclinical studies and a few early-phase human trials. Animal studies have demonstrated that pterostilbene can improve insulin sensitivity, reduce blood glucose, lower triglycerides, and decrease blood pressure—key components of metabolic syndrome. Mechanistically, these effects are thought to stem from its antioxidant and anti-inflammatory properties, as well as its ability to modulate lipid metabolism and activate AMPK pathways.
In humans, evidence is limited. A small number of clinical trials (e.g., Riche et al., 2014, Phytotherapy Research) have reported modest reductions in blood pressure and improvements in lipid profiles with pterostilbene supplementation, but the effects on glucose metabolism and overall metabolic syndrome parameters are inconsistent and generally not statistically robust. Larger, well-controlled studies are lacking, and there is not yet a consensus on efficacy or optimal dosing.
In summary, while there is a plausible biological rationale and encouraging preclinical evidence, the clinical data supporting pterostilbene's use for metabolic syndrome remain preliminary. Therefore, the evidence is rated as 2 on a 0-5 scale—suggestive but not conclusive. It is not a traditional remedy for this condition.
Other ingredients used for Metabolic Syndrome
7-hydroxymatairesinol (HMR)7-Keto-DHEA
acai berry
akkermansia muciniphila
algal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anchovies
anthocyanins
asparagus
bacillus subtilis
banaba
barley
berberine
Beta-Glucan
beta-sitosterol
bifidobacterium longum
bitter melon
black garlic
blueberry
brussel sprouts
butyrate triglyceride
campesterol
camu camu
canola oil
caterpillar mushroom
chia seed
chokeberry
chromium
cinnamon
conjugated linoleic acid (CLA)
turmeric
curcumin
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
flaxseed
fructooligosaccharides (FOS)
ginger
glucomannan
guar gum
hydroxycitric acid
inulin
krill oil
l-carnitine
lactobacillus helveticus
licorice root
mackerel
maitake mushroom
maqui berry
matcha
medium chain triglycerides (MCT)
moringa
naringin
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-7 fatty acids
omega-9 fatty acids
oyster mushroom
palmitoleic acid
quinoa
red yeast rice
reishi mushroom
resveratrol
rye
sardines
spirulina
tocotrienols
trans-pterostilbene
Urolithin A
vanadium
vanadyl sulfate
vitamin C
vitamin D
wheat grass
whey protein
xylooligosaccharides
zinc
β-nicotinamide mononucleotide (NMN)
algae
kidney beans
AMP-activated protein kinase (AMPK)
1-deoxynojirimycin
15,16-Dihydrotanshinone I
12-methylcarnosic acid
3-desoxy-7-KETO-DHEA
4-hydroxyisoleucine
5,7-Dimethoxyflavone
6-Paradol
Alpha Glucans
Ankaflavin
Apigenin
Aronia melanocarpa
Antrodia camphorata
Auricularia
Antirrhinin
Avocado
Ascophyllum nodosum
Acacetin
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Ampelopsin
Alpha phytosterol
Algal protein
Arabinoxylan
alpha Methyl Tetradecylthioacetic Acid
Arjunolic acid
Bifidobacterium adolescentis
Beta-hydroxybutyrate
Blakeslea trispora
Bean
Betanin
Brazil nut
Charantin
California chia
Cardarine
Cyanobacteria
Capsinoids
Cyanidin
chlorogenic acid
Capsiate
Chitin-Glucan Complex
Calanus finmarchicus
Crocetin
Cynaropicrin
Cystoseira canariensis
corosolic acid
Crypthecodinium
Carnosic acid
Docosahexaenoic Acid
Dunaliella
Dihydrocapsiate
Dragon Fruit
Dihydrolipoic Acid
D-Pinitol
Diosgenin
Ergothioneine
Evodiamine
Ecklonia
Fucosterol
Foxtail millet
Fucoxanthin
Flavanols
Fructan
Ginsenosides
Glucan peptides
Galactooligosaccharides
Guanidinopropionic Acid (GPA )
Guggulsterones
Glucoraphanin
Garbanzo bean
Glucosinolates
peanut
Pistachio
Other health conditions supported by Pterolstilbene
Aging (prevention)Alzheimer's Disease
Cancer (prevention)
Cardiovascular Disease
Cholesterol (high)
Diabetes
Inflammation
Memory and Brain Function
Metabolic Syndrome
Triglycerides (high)
