Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Mulberroside A is a bioactive compound found primarily in the root bark of Morus alba (white mulberry). Its use in supporting or treating Metabolic Syndrome is grounded in emerging preclinical scientific studies, rather than long-standing traditional use or robust clinical evidence. In several in vitro and animal studies, Mulberroside A has demonstrated beneficial effects on metabolic parameters relevant to Metabolic Syndrome, such as improving insulin sensitivity, reducing blood glucose levels, modulating lipid profiles, and exerting anti-inflammatory and antioxidant effects. For example, studies in high-fat diet-induced obese mice have shown that Mulberroside A can ameliorate hyperlipidemia and improve markers of insulin resistance, likely through modulation of pathways such as AMPK signaling and inhibition of adipogenesis.^[1][2] However, the evidence is currently limited to preclinical models; there is a lack of well-conducted human clinical trials directly assessing Mulberroside A for Metabolic Syndrome. The compound’s inclusion in supplements for metabolic health is largely based on these promising but preliminary findings. Therefore, while there is a scientific rationale for its use, the quality and quantity of evidence to support its efficacy in humans remain low, justifying a moderate evidence rating.

• ^[1] Pan, Y. et al. (2021). "Mulberroside A ameliorates metabolic disorders in high-fat diet-induced obese mice." Phytomedicine.
• ^[2] Kim, S.Y. et al. (2019). "Antidiabetic and hypolipidemic effects of mulberroside A." Journal of Ethnopharmacology.

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