Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Guggulsterone is a bioactive compound derived from the resin of the Commiphora mukul tree, commonly known as guggul. Traditionally, guggul has been used in Ayurvedic medicine for centuries to treat a variety of metabolic disorders, including obesity and lipid abnormalities. In recent decades, scientific research has investigated guggulsterone's potential mechanisms for managing metabolic syndrome, a cluster of conditions including obesity, dyslipidemia, hypertension, and insulin resistance.

Preclinical studies suggest that guggulsterone acts as an antagonist of the farnesoid X receptor (FXR), a nuclear receptor involved in cholesterol and bile acid metabolism. In animal models, guggulsterone has demonstrated lipid-lowering effects and some potential to improve insulin sensitivity. However, human clinical trials have produced inconsistent results. Some early studies suggested modest reductions in total cholesterol and LDL cholesterol, but larger, well-controlled trials have failed to demonstrate significant improvements in dyslipidemia, glucose metabolism, or other aspects of metabolic syndrome. Safety concerns such as skin rashes and gastrointestinal upset have also been reported.

Overall, while there is a plausible scientific rationale and some preclinical evidence for guggulsterone in metabolic syndrome, the clinical evidence in humans is limited and inconsistent. Therefore, its use is supported by scientific investigation but with weak to moderate evidence (rated 2/5).

More about Guggulsterone
More about Metabolic Syndrome

Other ingredients used for Metabolic Syndrome

Other health conditions supported by Guggulsterone

Products containing Guggulsterone