Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Docosahexaenoic acid (DHA) is an omega-3 fatty acid found primarily in fatty fish and algae. Its use in supporting or treating Metabolic Syndrome is primarily justified by scientific evidence, although the strength of this evidence is moderate and not unequivocal. Metabolic Syndrome is characterized by a cluster of conditions, including central obesity, dyslipidemia (abnormal lipid levels), insulin resistance, and hypertension, which together increase the risk of cardiovascular disease and type 2 diabetes.

Several clinical trials and meta-analyses have examined the effects of DHA, often in combination with eicosapentaenoic acid (EPA), on components of Metabolic Syndrome. DHA has been shown to improve triglyceride levels, reduce blood pressure modestly, and exert anti-inflammatory effects. For example, a 2020 meta-analysis published in Prostaglandins, Leukotrienes and Essential Fatty Acids reported that omega-3 supplementation, including DHA, can significantly reduce triglycerides and may improve other cardiovascular risk factors. Some studies also suggest potential improvements in insulin sensitivity and endothelial function, although findings are less consistent.

However, while DHA supplementation can improve certain biochemical markers associated with Metabolic Syndrome, robust evidence for its ability to reverse the syndrome as a whole or significantly reduce its incidence is still lacking. The American Heart Association recognizes omega-3s for cardiovascular risk reduction, primarily via triglyceride lowering, but does not specifically recommend DHA for Metabolic Syndrome per se. Overall, the scientific basis for DHA’s use in Metabolic Syndrome is credible but not definitive, warranting a moderate evidence score.

More about DHA (docosahexaenoic acid)
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Other ingredients used for Metabolic Syndrome

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Products containing DHA (docosahexaenoic acid)

Nature's Sunshine Circulatory System
Nature's Sunshine Krill Oil (With Vitamin K2)
Nature's Sunshine Super Trio