Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Estrogen is scientifically validated for use in the treatment of scant menstruation (hypomenorrhea), particularly when the cause is related to hormonal imbalance or estrogen deficiency. Estrogen plays a key role in regulating the menstrual cycle by stimulating the growth of the endometrial lining during the follicular phase. When endogenous estrogen levels are insufficient, the endometrium may not proliferate adequately, leading to scant or absent menstrual periods.

Clinical guidelines and medical literature support the use of estrogen, often in combination with progestins, as a part of hormone therapy to restore normal menstrual cycles in women with hypomenorrhea due to hypogonadism, premature ovarian insufficiency, or other endocrine disorders. Numerous studies have demonstrated that estrogen replacement can effectively induce endometrial proliferation and restore normal menstrual bleeding patterns in these populations (source). However, in women with functional hypothalamic amenorrhea or other non-hormonal causes, the benefit is limited unless the underlying cause is addressed.

The evidence is strong (rated 4 out of 5) for estrogen’s efficacy in cases where hormonal imbalance is the underlying etiology. However, inappropriate use without proper diagnosis can carry risks, and estrogen therapy should be tailored to individual patient needs under medical supervision.

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