Evidence supporting the use of: Vitamin B6
For the health condition: Menstrual Irregularity

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Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Vitamin B6 (pyridoxine) has traditionally been used to support menstrual irregularities, often as part of broader vitamin or nutritional interventions for women’s reproductive health. The rationale is based on its role in neurotransmitter synthesis (such as serotonin and dopamine) and its involvement in hormone metabolism, which are thought to influence the menstrual cycle and premenstrual symptoms. However, the direct evidence supporting its effectiveness specifically for treating menstrual irregularity is very limited. Most of the available scientific research focuses on vitamin B6 for premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD), with some studies suggesting modest benefits in reducing mood-related symptoms. There are very few clinical trials examining vitamin B6 for irregular menstrual cycles, and those that exist are often small or methodologically weak. Thus, while vitamin B6 use for menstrual irregularity persists in traditional and alternative medicine circles, it is not strongly backed by robust scientific evidence. For menstrual irregularity, addressing underlying causes (such as polycystic ovary syndrome, thyroid dysfunction, or other hormonal imbalances) is generally recommended over relying on vitamin B6 supplementation. In summary, vitamin B6’s use for menstrual irregularity is rooted more in tradition and extrapolation from related conditions than in solid scientific validation.

More about vitamin B6
More about Menstrual Irregularity

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