Squaw Vine (Mitchella repens) has a long history of use in North American Indigenous herbal traditions and by 19th-century American herbalists, particularly as a remedy for women’s health concerns, including menstrual irregularity. It was often included in formulas intended to tone the uterus, regulate the menstrual cycle, or prepare women for childbirth. The use of Squaw Vine for menstrual irregularity is thus primarily justified by traditional and folkloric practices rather than modern scientific evidence.

Contemporary scientific studies validating the efficacy or safety of Squaw Vine for menstrual irregularity are lacking. There are no well-designed clinical trials or pharmacological studies that support its use for this specific condition. The available evidence consists primarily of anecdotal reports, traditional herbal texts, and ethnobotanical records. Some sources note its mild sedative and antispasmodic properties, which may have contributed to its use for menstrual discomfort or irregularity, but these effects have not been rigorously investigated or confirmed in humans.

In summary, the use of Squaw Vine for menstrual irregularity is based on traditional herbal medicine rather than scientific validation. Evidence quality is low, and those considering its use should consult qualified healthcare professionals, especially given the absence of clinical data.