Aletris, commonly known as "unicorn root," has a history of use in traditional herbal medicine, particularly within North American indigenous and 19th-century eclectic medical practices. It was often recommended for "female complaints," including menstrual irregularity, dysmenorrhea (painful menstruation), and other gynecological issues. These recommendations were largely based on anecdotal evidence and the doctrine of signatures, rather than controlled scientific studies.

Despite its long-standing historical use, there is a notable lack of robust scientific research or clinical trials to support the efficacy of Aletris in treating menstrual irregularities. Most modern herbal references cite its traditional usage but caution that there is insufficient pharmacological or clinical data to confirm its benefits for menstrual health. The main constituents of Aletris, such as steroidal saponins, have not been specifically investigated for effects on menstrual cycles in humans.

In summary, Aletris's use for menstrual irregularity is rooted in tradition rather than scientific validation. While it remains a part of herbal folklore and historical medical texts, the evidence supporting its effectiveness is weak and primarily based on historical precedent rather than rigorous modern research.