Evidence supporting the use of: Vitamin D3
For the health condition: Menopause

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D3 is used to support menopausal health primarily on the basis of scientific rationale, although the strength of evidence is modest. During menopause, declining estrogen levels contribute to an increased risk of osteoporosis and decreased bone mineral density. Vitamin D3 (cholecalciferol) plays a critical role in calcium absorption and bone metabolism. Several guidelines recommend ensuring adequate vitamin D status in peri- and postmenopausal women to maintain bone health and reduce the risk of fractures. Clinical studies demonstrate that low vitamin D levels are common in postmenopausal women and are associated with greater bone loss and higher fracture risk.

However, randomized controlled trials examining vitamin D supplementation in menopausal women have shown mixed results regarding its ability to reduce fracture risk or improve bone mineral density independently of calcium. Most benefits are observed when vitamin D3 is combined with calcium supplementation. There is limited evidence that vitamin D3 alone alleviates other menopausal symptoms such as hot flashes, mood changes, or sleep disturbances.

In summary, the use of vitamin D3 during menopause is scientifically justified for maintaining bone health and preventing osteoporosis, especially in women with inadequate levels. Its role in managing other menopausal symptoms is not well established. The evidence supports its use mainly for bone-related outcomes, earning a moderate evidence score.

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