Rhubarb, specifically extracts from Rheum rhaponticum (Siberian rhubarb), has some scientific validation for use in supporting menopausal symptoms. The extract, often standardized to contain rhaponticin and its derivatives, has been studied for its effects on menopausal complaints such as hot flashes, night sweats, and mood disturbances. Several randomized, double-blind, placebo-controlled clinical trials have been conducted, primarily in Europe, using a proprietary extract (ERr 731). These studies generally report a statistically significant reduction in the frequency and severity of menopausal symptoms compared to placebo, as measured by the Menopause Rating Scale (MRS).

The proposed mechanism involves selective modulation of estrogen receptor beta (ER-β), which may help alleviate symptoms without the risks associated with traditional hormone replacement therapy. Notably, the studies have shown a good safety profile for the extract, with adverse events comparable to placebo.

However, the number of independent studies is limited, and most research is tied to a specific commercial extract. While the evidence base is stronger than for many herbal remedies, more large-scale, independent trials would further clarify its efficacy and safety. Traditional use of rhubarb for menopause is not well-documented; its use for this purpose is primarily a modern development based on recent scientific exploration.