Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Melatonin, a hormone primarily known for regulating sleep-wake cycles, has been investigated for its potential role in supporting menopausal women, primarily due to its influence on sleep disturbances and circadian rhythm disruptions that often accompany menopause. Several small-scale clinical studies have explored melatonin’s effects on menopausal symptoms, especially insomnia, which is a common complaint during this period due to hormonal fluctuations. The evidence suggests that melatonin supplementation may help improve sleep quality and reduce the time it takes to fall asleep in peri- and postmenopausal women. Additionally, some research has posited that melatonin could have indirect benefits on mood regulation and may help modulate other menopausal symptoms, such as hot flashes, through its interaction with the endocrine system.

However, the scientific evidence is limited and not robust. The studies conducted have generally been small, short-term, and sometimes lack rigorous controls. Meta-analyses and systematic reviews have concluded that while melatonin shows promise for improving sleep in menopausal women, there is insufficient high-quality evidence to recommend it as a primary treatment for other menopausal symptoms. Major guidelines do not currently endorse melatonin as a standard therapy for menopause itself, but it may be considered for sleep disturbances when other interventions are unsuitable. In summary, there is moderate scientific rationale for melatonin's use in menopause—primarily for sleep support—but its overall evidence base remains weak.

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Nature's Sunshine Melatonin Extra