Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lignans are a group of phytoestrogens—plant-derived compounds with estrogen-like activity—found in high amounts in flaxseed, sesame seeds, and some whole grains. Their structural similarity to endogenous estrogens allows them to weakly bind to estrogen receptors, which has led to scientific interest in their potential role in alleviating menopausal symptoms, particularly vasomotor symptoms such as hot flashes. Several small-scale randomized controlled trials have investigated the effects of lignan-rich flaxseed supplementation on menopausal symptoms, with mixed results. Some studies have reported modest reductions in hot flash frequency and severity, while others have found no significant benefit compared to placebo. Systematic reviews and meta-analyses generally conclude that the evidence is limited and inconsistent, and that larger, well-designed studies are needed.

The proposed mechanism is that lignans may exert mild estrogenic or anti-estrogenic effects depending on endogenous estrogen levels, potentially helping to balance hormonal fluctuations during menopause. However, the effect size is small and variable. While lignans are sometimes recommended as a natural option for menopausal symptom relief, their efficacy remains scientifically unproven beyond a modest effect, and they are not considered a first-line therapy by major medical organizations. Safety profiles are generally favorable, as lignans are common in foods, but high-dose supplements should be used with caution. In summary, scientific evidence for lignans in menopause is limited and not robust, justifying a low evidence rating.

More about Lignan
More about Menopause

Other ingredients used for Menopause

Other health conditions supported by Lignan

Products containing Lignan