Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Isoflavones, primarily derived from soy, are plant-based compounds classified as phytoestrogens due to their structural similarity to human estrogen. Their use in supporting or treating menopause is justified by a growing body of scientific research, though the overall quality and consistency of evidence is moderate rather than definitive. Isoflavones are thought to exert mild estrogenic effects, which may alleviate menopausal symptoms such as hot flashes, night sweats, and vaginal dryness, particularly in women who experience a decline in endogenous estrogen levels.

Several randomized controlled trials (RCTs) and meta-analyses have evaluated the efficacy of isoflavones for menopausal symptom relief. Some studies report modest reductions in the frequency and severity of hot flashes compared to placebo, especially in women with more severe baseline symptoms. For example, a 2021 Cochrane review concluded that isoflavones may slightly reduce the frequency of hot flushes in menopausal women, but the clinical significance is uncertain and results are inconsistent. Other meta-analyses suggest benefits are greatest when isoflavone intake is sufficiently high and sustained over weeks to months.

However, not all studies show significant improvements, and there is considerable variability in results based on the population studied, isoflavone source, and dose. Safety profiles are generally favorable, but long-term effects remain under investigation. In summary, there is scientific evidence supporting the use of isoflavones for menopausal symptom relief, but it is moderate in strength and not universally conclusive.

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