Synopsis

Source of validity: Scientific
Rating (out of 5): 2

HMR lignan, also known as 7-hydroxymatairesinol, is a plant lignan primarily sourced from the Norway spruce. It is converted by intestinal bacteria into enterolactone, a mammalian lignan with weak estrogenic activity. The rationale for using HMR lignan to support menopause stems from its phytoestrogen properties, which theoretically may help balance declining estrogen levels during menopause, thereby alleviating symptoms such as hot flashes and mood swings.

However, scientific evidence supporting HMR lignan’s effectiveness for menopause is limited. Some small-scale studies and preclinical research have shown that enterolactone may exert mild estrogenic effects, potentially influencing hormone-related symptoms. A few clinical trials have examined its impact on lipid profiles, bone health, and breast cancer risk, but data specifically targeting menopausal symptoms are scarce. Most available studies are either animal-based, in vitro, or focused on general hormone modulation rather than direct symptom relief in menopausal women.

In summary, while there is a plausible biological mechanism and some early scientific interest in HMR lignan for menopause, robust clinical evidence is lacking. The current use of HMR lignan for menopausal support is therefore based on limited scientific validation, with an evidence rating of 2/5.

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