Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Glycetein is an isoflavone compound found in soy and other legumes. Isoflavones, including glycetein, are classified as phytoestrogens—plant-derived compounds with estrogen-like activity. Scientific interest in soy isoflavones for menopause stems from epidemiological observations that populations consuming high-soy diets (notably in some Asian countries) report fewer and less severe menopausal symptoms, such as hot flashes. Clinical studies have primarily focused on genistein and daidzein, the two main soy isoflavones, but glycetein is also a component of soy extracts used in research and supplements.

Studies on soy isoflavones suggest a modest benefit for alleviating vasomotor symptoms (hot flashes and night sweats) and possibly for supporting bone health during menopause. The mechanism is thought to involve weak estrogen receptor modulation by isoflavones, which can partially compensate for declining endogenous estrogen levels in menopausal women. Glycetein has weaker estrogenic activity compared to genistein and daidzein, but may contribute to the overall effect of soy isoflavone mixtures.

Systematic reviews and meta-analyses indicate that soy isoflavone supplementation can reduce the frequency and severity of hot flashes compared to placebo, although the clinical significance is debated and individual responses vary. Glycetein-specific research is limited, but its inclusion in standardized soy isoflavone supplements, which are supported by clinical trials, underpins its use. Therefore, there is scientific (though not robust or glycetein-specific) evidence for its use in menopause.

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