Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Genistein is an isoflavone predominantly found in soy products, and its use in managing menopausal symptoms is primarily supported by scientific research. Genistein is classified as a phytoestrogen, meaning it can bind to estrogen receptors and exert mild estrogen-like effects in the body. During menopause, endogenous estrogen levels decline, leading to symptoms such as hot flashes, night sweats, and osteoporosis risk. Several randomized controlled trials and meta-analyses have shown that genistein supplementation, particularly at doses of 30–54 mg/day, can moderately reduce the frequency and severity of vasomotor symptoms (like hot flashes) in menopausal women compared to placebo. Additionally, there is some evidence that genistein may help maintain bone mineral density by mimicking the bone-protective effects of estrogen. However, the quality and consistency of evidence varies. Some studies show a modest but statistically significant benefit, while others do not find a meaningful effect. Genistein appears to be most effective in women who have low dietary intake of soy. Safety profiles are generally favorable for short-term use, but long-term effects are less well established. While not as potent as hormone replacement therapy, genistein is considered a reasonable alternative for women seeking non-hormonal options for menopause symptom management. In summary, scientific evidence supports the use of genistein for menopause, but its efficacy is moderate and not universal.

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