Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flax lignans, particularly secoisolariciresinol diglucoside (SDG), are phytoestrogens found in flaxseed. These compounds can be converted in the gut to enterolignans, which have weak estrogenic and anti-estrogenic effects. The theoretical rationale for using flax lignans during menopause centers on their potential to modulate estrogen activity, which may help alleviate symptoms such as hot flashes and night sweats. Several small randomized controlled trials and observational studies have investigated the effect of flaxseed or flax lignans on menopausal symptoms. Some have reported modest reductions in hot flash frequency and severity compared to placebo, while others have found no significant benefit. A 2013 systematic review (Lecomte et al., Maturitas) concluded that evidence supporting flaxseed or lignans for menopausal symptom relief is inconsistent and generally of low quality. More recent meta-analyses echo this uncertain benefit, citing heterogeneity in study designs, dosages, and outcome measures. Overall, while there is some scientific interest and preliminary data suggesting flax lignans might offer mild relief for menopausal symptoms, the evidence is limited and not robust. Major clinical guidelines do not currently recommend flax lignans as a standard therapy for menopause, but they are sometimes used as an alternative by individuals seeking non-hormonal options. More rigorous, large-scale studies are needed to confirm efficacy and safety.

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