Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavonones are a subclass of flavonoids found in various fruits and vegetables, particularly citrus fruits. Their use in supporting or treating menopause is primarily based on their phytoestrogenic properties—meaning they can mildly mimic or modulate estrogenic activity in the body. Scientific studies have investigated certain flavonones, such as hesperidin and naringenin, for their antioxidant, anti-inflammatory, and potential estrogenic effects. Some in vitro and animal studies have suggested that these compounds may bind to estrogen receptors and exert weak estrogen-like effects, which could theoretically alleviate menopausal symptoms such as hot flashes and bone loss.

However, human clinical evidence is limited and inconsistent. A few small clinical studies have examined citrus flavonones’ effects on menopausal symptoms, with some reporting modest improvement in hot flashes and general well-being, while others found no significant effects. Notably, systematic reviews and meta-analyses conclude that, although flavonoids (including flavonones) may offer some benefit for menopausal symptom relief, the overall quality of evidence is low, and results are not robust or consistent enough to recommend them as a primary treatment. Larger, well-designed randomized controlled trials are lacking. Thus, while there is some scientific rationale and preliminary evidence, the use of flavonones for menopause is not strongly validated at this time.

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