Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Equol is a metabolite of the soy isoflavone daidzein, produced by certain gut bacteria. Its use for menopause support is justified by emerging scientific evidence, rather than traditional use, as equol itself is not present in significant amounts in foods or herbal remedies. Several clinical studies have investigated the effects of equol supplementation—particularly the proprietary S-equol form—on menopausal symptoms such as hot flashes, night sweats, and mood disturbances. Results indicate modest but significant improvements in vasomotor symptoms and quality of life in peri- and postmenopausal women, especially among those who do not naturally produce equol after consuming soy. Mechanistically, equol is a selective estrogen receptor modulator (SERM), binding preferentially to estrogen receptor beta, which is believed to mediate many beneficial effects in menopausal symptom relief without the risks associated with conventional hormone therapy. The evidence base includes randomized controlled trials and meta-analyses, but limitations such as relatively small sample sizes, short study durations, and heterogeneity in outcome measures exist. Nonetheless, regulatory agencies in some countries (e.g., Japan) recognize equol supplements for managing menopausal symptoms. Overall, equol's use is supported by moderate scientific evidence, with ongoing research aimed at clarifying its long-term safety and effectiveness.

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Other ingredients used for Menopause

Other health conditions supported by Equol (proprietary)

Products containing Equol (proprietary)

Nature's Sunshine Equolibrium™