Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Diindolylmethane (DIM) is a compound formed in the body during the digestion of indole-3-carbinol, which is found in cruciferous vegetables like broccoli and Brussels sprouts. The primary rationale for its use in menopause is its influence on estrogen metabolism. Some in vitro and animal studies, as well as limited human data, suggest that DIM promotes the conversion of estrogen to less potent, potentially protective metabolites. This has led to the hypothesis that DIM may help balance estrogen levels during menopause, potentially alleviating symptoms such as hot flashes or supporting overall hormonal health.

Despite these mechanisms, high-quality clinical evidence supporting DIM’s effectiveness for treating or supporting menopause is limited. A few small-scale studies have examined DIM’s effects on hormone metabolism in postmenopausal women, but results are preliminary and do not robustly demonstrate symptom relief or major health benefits. The evidence base is therefore weak, with most support coming from mechanistic studies or extrapolation from its effects on estrogen metabolism, rather than from rigorous trials assessing menopause symptoms directly.

In summary, while there is a scientific rationale and some preclinical and early clinical evidence supporting DIM’s use in menopause, current data are insufficient to confirm its effectiveness. More large-scale, well-designed clinical trials are needed to establish its efficacy and safety for menopausal symptom management.

More about Diindoylmethane
More about Menopause

Other ingredients used for Menopause

Other health conditions supported by Diindoylmethane

Products containing Diindoylmethane