Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, a substance found in cruciferous vegetables such as broccoli and kale. Its use in menopause is based on its ability to influence estrogen metabolism. Specifically, DIM promotes the conversion of estradiol (a potent form of estrogen) into less potent, “good” estrogen metabolites. This has led to hypotheses and preliminary research suggesting that DIM may help balance estrogen levels and alleviate some symptoms associated with menopause, such as hot flashes and night sweats.

Scientific validation for DIM’s effectiveness in menopause is limited. Most studies focus on its role in estrogen metabolism and its potential impact on hormone-related cancers, rather than direct menopausal symptom relief. A few small clinical studies and animal models suggest possible benefits for hormone balance, but robust randomized controlled trials in menopausal women are lacking. Therefore, evidence supporting DIM’s use for menopause is weak (rated 2/5). It is sometimes used by practitioners as an “estrogen balancer” during menopause, but this is primarily extrapolated from biochemical studies and not direct clinical evidence.

In summary, while there is some scientific rationale and preliminary evidence for using DIM to support menopause, high-quality clinical trials confirming efficacy and safety are lacking. Use should be considered experimental and discussed with a healthcare provider.