Cynanchum wilfordii is an herb traditionally used in East Asian medicine, particularly in Korea and China, for various health concerns, including symptoms associated with menopause. Its use is primarily rooted in traditional practices, where it is believed to support hormonal balance, alleviate hot flashes, and improve overall vitality in menopausal women. In Korean traditional medicine, Cynanchum wilfordii is often included in herbal formulas aimed at nourishing "yin" and supporting reproductive health.

Scientific research on Cynanchum wilfordii for menopause is limited. Some small clinical trials and preclinical studies have investigated its effects on estrogen levels, bone density, and menopausal symptoms, but results remain inconclusive and sample sizes are often small. While some evidence suggests potential estrogenic effects and antioxidant properties, these findings are not robust enough for widespread medical endorsement. Moreover, safety concerns regarding possible adulteration with related species (notably Cynanchum auriculatum) and related adverse events have been raised, especially in the context of commercial supplements.

In summary, the use of Cynanchum wilfordii to support menopause is primarily grounded in tradition. Scientific evidence remains preliminary and does not yet provide strong validation for its efficacy or safety in managing menopausal symptoms.