Synopsis

Source of validity: Scientific
Rating (out of 5): 2

7-hydroxymatairesinol (HMR) is a lignan compound found primarily in the heartwood of the Norway spruce (Picea abies). It is a phytoestrogen, meaning it has a chemical structure similar to estrogen and can exert weak estrogen-like effects in the body. The rationale for using HMR to support menopause relates to the decline in endogenous estrogen in menopausal women, which is associated with symptoms such as hot flashes, night sweats, and increased risk of osteoporosis and cardiovascular issues. Several preclinical studies have shown that HMR and its metabolites can bind to estrogen receptors and may have beneficial effects on bone health and lipid metabolism in animal models. A few small-scale human studies and pilot trials have explored HMR supplementation in postmenopausal women, indicating mild improvements in some menopausal symptoms and markers of bone turnover, but the evidence base is limited and studies are often short-term, with small sample sizes and inconsistent results.

Overall, while there is a plausible scientific mechanism and some preliminary human data suggesting potential benefits of HMR for menopause-related symptoms, the clinical evidence is currently insufficient to strongly support its use. Large, high-quality randomized controlled trials are lacking. Thus, the use of HMR for menopause is scientifically motivated, but the strength of evidence is weak at this time (rated 2/5).

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