Synopsis

Source of validity: Traditional
Rating (out of 5): 2

27-deoxyactein is a triterpene glycoside found in the root of Actaea racemosa (black cohosh), an herb traditionally used by Native American peoples and later adopted in Europe and North America for managing menopausal symptoms such as hot flashes, night sweats, and mood disturbances. The use of black cohosh (and by extension, its constituent 27-deoxyactein) for menopause is thus primarily rooted in traditional and historical herbal medicine practices.

Scientific studies have examined black cohosh extracts (often standardized to contain triterpene glycosides, including 27-deoxyactein), but the evidence for efficacy remains mixed. While some clinical trials and systematic reviews suggest a modest benefit in reducing vasomotor symptoms, others indicate no significant difference from placebo. Most studies do not isolate 27-deoxyactein as the sole active constituent; rather, whole-root or standardized extracts are tested. The mechanism of action is not fully understood, but black cohosh does not appear to exert estrogenic effects, and 27-deoxyactein's specific role is unclear.

Due to the preponderance of traditional use and limited, inconsistent scientific validation, the evidence supporting 27-deoxyactein (as part of black cohosh) for menopause is rated as 2/5. The ingredient is widely used in traditional herbal formulas, but robust, high-quality clinical data specifically supporting 27-deoxyactein is lacking.

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