Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B1 (thiamine HCl) has a scientifically recognized role in supporting brain function, primarily because of its necessity for normal neuronal metabolism and neurotransmitter synthesis. Severe thiamine deficiency is well known to cause neurological syndromes like Wernicke-Korsakoff syndrome, characterized by memory impairment, confusion, and other cognitive deficits. Supplementation with thiamine is a validated treatment for these deficiency-related syndromes, particularly in populations at risk (e.g., chronic alcoholics, malnourished individuals, or those with certain medical disorders).

However, for the general population or as a means to enhance memory and cognitive function in otherwise healthy individuals, the evidence is considerably less robust. Most studies in non-deficient populations have failed to show significant benefit from thiamine supplementation on memory or general brain function. Some small trials have suggested possible improvement in cognitive performance with high-dose thiamine in older adults, but results are inconsistent and generally not considered strong enough to recommend routine use for memory support.

In summary, while thiamine is essential for brain health and its supplementation is scientifically validated for preventing and treating deficiency-related cognitive disorders, there is limited and weak evidence for its use in improving memory or brain function in those without deficiency.

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