Evidence supporting the use of: SOD (Superoxide Dismutase, antioxidant activity)
For the health condition: Memory and Brain Function

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Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Superoxide Dismutase (SOD) is an endogenous antioxidant enzyme that plays a critical role in protecting cells from oxidative stress by catalyzing the conversion of superoxide radicals into hydrogen peroxide and oxygen. Oxidative stress has been implicated in neurodegenerative diseases and cognitive decline, leading to interest in antioxidants like SOD for supporting brain and memory function. Several preclinical studies in animal models have suggested that increasing SOD activity may provide neuroprotection and improve cognitive performance under oxidative stress conditions. However, the evidence from human studies is extremely limited. The primary challenge is that orally administered SOD is rapidly degraded in the gastrointestinal tract, resulting in very low bioavailability. A few small-scale clinical trials with SOD formulations designed to enhance stability (e.g., coated SOD or SOD-rich melon extract) have reported mild improvements in cognitive parameters or reductions in oxidative stress markers, but these studies are preliminary and often suffer from methodological limitations. There is currently insufficient high-quality clinical evidence to support the use of SOD supplements for memory or brain function, and major medical and scientific organizations do not recommend SOD for this indication. Thus, while the rationale is grounded in plausible mechanisms, the actual evidence supporting SOD supplementation for cognitive health in humans is weak.

More about SOD (Superoxide Dismutase, antioxidant activity)
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Other ingredients used for Memory and Brain Function

2'-Fucosyllactose
acai berry
acetyl l-carnitine
algal oil
alpha-pinene
amino acids
anchovies
anthocyanins
ashwagandha
asparagus
astaxanthin
waterhyssop
beet
berry flavor
beta caryophyllene
bifidobacterium longum
bilberry
black currant
black garlic
sesame
black tea
blackberry
blueberry
Indian frankincense
broccoli
caprylic acid
catechins
caterpillar mushroom
chaga mushroom
Chinese salvia root
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
cordyceps
creatine monohydrate
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish protein
folate
fruit and vegetable blend (proprietary)
fruit blend (proprietary)
ginkgo biloba
glycerophosphocholine (GPC)
gooseberry
gotu kola
grape
green tea
guarana
guayusa
hesperetin
huperzine A
inositol
jujube
kale
krill oil
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
l-carnitine
l-carnosine
l-serine
l-taurine
l-theanine
l-tyrosine
lactobacillus reuteri
lecithin
lion's mane
lutein
luteolin
maca
mackerel
marine lipid
matcha
medium chain triglycerides (MCT)
moringa
muira puama
Acetyl-L-Tyrosine
naringin
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oat
oleic acid
olive
omega-3 fatty acids
ophiopogon root
perilla
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
pine bark
pollen
polygala root
pomegranate
pregnenolone
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quail egg
quercetin
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resveratrol
rhodiola
rutin
saffron
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
selenium
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specialized pro-resolving mediators (SPMs)
spinach
spirulina
strawberry
sulforaphane glucosinolate
threonic acid
tocotrienols
tomato
trans-pterostilbene
almond fruit
ubiquinol
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vegetable and fruit blend (proprietary)
velvet bean
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vitamin B12
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vitamin C
vitamin D
vitamin D3
vitamin E
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zinc
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lingzhi
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ferulic acid
chrysanthemum
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lotus seed
royal jelly
terpene lactones
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yerba mate
biota seed
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cocoa
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3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
5-methyltetrahydrofolate glucosamine
7,8-Dihydroxyflavone
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Aronia melanocarpa
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Alpha glyceryl
Andrographolide
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Agmatine
Adrafinil
Acetylcholine
Amentoflavone
Agarwood
Acacetin
Alpha-Lipoic Acid
anthocyanidins
Ampelopsin
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anthocyanosides
Black Seed
Bilobalide
Butylphthalide
Beta-hydroxybutyrate
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Boswellia
Brahmi
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Bifidobacteria
bacoside
Baicalin
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Centrophenoxine
Camellia sinensis
Centella triterpenes
Chinese Mountain Ant
Cyanobacteria
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Catalpol
Chebulic acid
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Codonopsis
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Chocolate
Chinese Ligustrum berry
Creatine
Catuaba
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Cytidine
cola nut
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Currant
Carnosic acid
Docosahexaenoic Acid
Danshen
Dendrobium
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epicatechin
Egg
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Eucommia ulmoides
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Fo-Ti
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glucose
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walnut
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Products containing SOD (Superoxide Dismutase, antioxidant activity)

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