Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Phospholipids, particularly phosphatidylserine (PS) and phosphatidylcholine (PC), have been studied for their potential roles in supporting memory and brain function. These compounds are major components of neuronal cell membranes and are crucial for maintaining membrane fluidity and facilitating signaling pathways in the brain. Clinical research has investigated the effects of supplemental phospholipids—most notably PS—on cognitive function, especially in elderly individuals or those with cognitive decline.

Several randomized, double-blind, placebo-controlled trials have suggested that PS supplementation may improve memory, cognition, and mood in older adults with mild cognitive impairment or age-associated memory decline. For example, a 2010 review (Jorissen et al., 2001; Crook et al., 1991) found that 300 mg/day of PS for 3–6 months produced modest but statistically significant improvements in memory and cognitive parameters. However, the effects in healthy adults are less well established, and the benefits appear to be more pronounced in individuals with existing cognitive challenges.

Phosphatidylcholine, as a precursor to the neurotransmitter acetylcholine, has also been studied, but results have been inconsistent and generally less promising than those for PS. Overall, the use of phospholipids for memory and brain function is scientifically justified, with moderate-quality evidence (evidence rating: 3/5), particularly for phosphatidylserine in older adults experiencing cognitive decline.

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