Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Evidence for Ginkgo Flavone Glycoside in Memory and Brain Function

Ginkgo flavone glycosides are key active compounds found in Ginkgo biloba leaf extracts, which have a long history of traditional use in Chinese medicine for improving cognitive function. In modern times, standardized Ginkgo extracts (typically containing 24% flavone glycosides and 6% terpene lactones) have been studied for their effects on memory and brain function, particularly in the context of age-related cognitive decline and dementia.

Scientific evidence is mixed but suggests only modest benefit. Several meta-analyses and randomized controlled trials have indicated that Ginkgo biloba extract may offer small improvements in cognitive performance and activities of daily living in patients with mild to moderate dementia or Alzheimer’s disease. The proposed mechanisms include antioxidant effects, improved cerebral blood flow, and neuroprotective properties linked to the flavone glycosides. However, large, well-controlled studies such as the Ginkgo Evaluation of Memory (GEM) study have not found significant benefits in preventing cognitive decline in healthy older adults.

Overall, while there is scientific validation for the use of Ginkgo flavone glycosides in supporting memory and brain function, especially in dementia, the magnitude of effect is generally small and evidence quality is moderate. Therefore, the evidence rating is 2 out of 5.

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