Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Fisetin is a flavonoid found in fruits and vegetables such as strawberries, apples, and onions. Scientific interest in fisetin's effects on memory and brain function stems from its antioxidant, anti-inflammatory, and neuroprotective properties observed in preclinical studies. In animal models, fisetin has shown promise in improving cognitive function, reducing oxidative stress in the brain, and protecting neurons from damage. For example, rodent studies have demonstrated that fisetin supplementation can mitigate memory loss induced by neurodegenerative processes or aging, and may even enhance learning and memory in healthy animals.

Mechanistically, fisetin appears to influence pathways involved in neuronal survival, reduce accumulation of toxic proteins such as amyloid-beta, and support synaptic plasticity, which is important for learning and memory. Despite these promising results in laboratory and animal studies, human clinical research is extremely limited. As of 2024, only a few small-scale clinical trials have been initiated to investigate fisetin's effects on cognitive decline or neurodegenerative diseases in humans, and definitive conclusions cannot yet be drawn.

In summary, while fisetin shows scientific potential for supporting memory and brain function based on preclinical data, robust clinical evidence in humans is currently lacking, resulting in a moderate rating of 2 out of 5 for the strength of evidence.

More about fisetin
More about Memory and Brain Function

Other ingredients used for Memory and Brain Function

Other health conditions supported by fisetin

Products containing fisetin