Ferulic acid is a plant-derived phenolic compound found in the cell walls of many plants, especially in grains like rice and wheat. Its use for supporting memory and brain function is primarily based on preclinical (animal and in vitro) studies suggesting antioxidant, anti-inflammatory, and neuroprotective effects. In particular, ferulic acid and some of its derivatives have been shown to reduce oxidative stress and inhibit amyloid-beta aggregation in animal models of Alzheimer’s disease. Some studies report improvements in cognitive performance in rodents treated with ferulic acid, attributed to its ability to modulate neurotransmitter systems and suppress neuroinflammation. Additionally, combination formulations such as "ferulic acid derivatives with other compounds" (for example, in the Japanese prescription drug Kremezin for chronic kidney disease, or in research compounds) have shown some promise in animal models of neurodegeneration.

However, robust clinical evidence in humans is lacking. There are only a few small-scale human studies or case reports, and these are typically preliminary. No large, high-quality randomized controlled trials have demonstrated significant benefit for memory or cognitive decline in humans. Thus, while there is a scientific rationale and encouraging preclinical data, the strength of evidence is currently limited, with a need for more rigorous human studies before ferulic acid derivatives can be conclusively recommended for brain health or memory support.