Evidence supporting the use of: Eicosapentaenoic Acid
For the health condition: Memory and Brain Function

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Eicosapentaenoic Acid (EPA) is an omega-3 polyunsaturated fatty acid found primarily in fish oil. Its use to support memory and brain function is rooted in scientific research, though the strength of evidence is moderate and sometimes inconsistent. Several observational and interventional studies have investigated the potential cognitive benefits of EPA, often alongside docosahexaenoic acid (DHA), another important omega-3 fatty acid. Some epidemiological studies suggest that higher dietary intake of omega-3 fatty acids is associated with reduced risk of cognitive decline and dementia in older adults. Randomized controlled trials, however, have produced mixed results: some show modest benefits in cognitive performance or slower cognitive decline, while others find no significant effect. The mechanisms proposed include EPA’s anti-inflammatory properties and its role in maintaining neuronal membrane fluidity, which may support neurotransmission and protect against neurodegeneration. Nevertheless, most of the cognitive benefits observed in clinical studies are attributed more to DHA than EPA, and many supplements contain both, making it difficult to isolate EPA’s specific effects. Current guidelines do not recommend EPA supplementation specifically for cognitive support, but ongoing research continues to explore its potential role. Therefore, while scientific rationale exists, robust clinical evidence for EPA alone in supporting memory and brain function remains limited.

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Other ingredients used for Memory and Brain Function

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algal oil
alpha-pinene
amino acids
anchovies
anthocyanins
ashwagandha
asparagus
astaxanthin
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beet
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beta caryophyllene
bifidobacterium longum
bilberry
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sesame
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broccoli
caprylic acid
catechins
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choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
cordyceps
creatine monohydrate
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish protein
folate
fruit and vegetable blend (proprietary)
fruit blend (proprietary)
ginkgo biloba
glycerophosphocholine (GPC)
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inositol
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l-carnitine
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l-serine
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lecithin
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Products containing Eicosapentaenoic Acid

We currently have no products on Caring Sunshine that contain this ingredient.