Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Butylphthalide, specifically dl-3-n-butylphthalide (NBP), is a compound originally isolated from celery seed and has been studied primarily in China for its neuroprotective effects. The principal scientific validation for its use comes from clinical trials and animal studies investigating its role in stroke recovery and vascular dementia. Several randomized controlled trials in China have shown that NBP can improve cognitive function and neurological outcomes in patients with ischemic stroke and vascular dementia, likely due to its abilities to improve microcirculation, reduce oxidative stress, and inhibit neuronal apoptosis. Some studies also suggest benefits in models of Alzheimer’s disease, but robust clinical evidence in non-vascular dementias is limited. Meta-analyses of Chinese trials generally report positive effects, but these studies are sometimes limited by sample size, methodology, and lack of western replication. NBP is approved in China for ischemic stroke, and its positive effects on cognitive recovery post-stroke have led to its use for supporting memory and brain function, particularly in vascular etiologies. However, outside China, its use is not widely adopted, and more large-scale, international, placebo-controlled trials are needed. Thus, while there is scientific evidence for the use of butylphthalide in supporting memory and brain function, particularly after stroke, the strength of evidence is moderate, meriting a rating of 3 out of 5.

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