Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bifidobacterium longum is a probiotic bacterium that has been the subject of increasing research interest for its potential effects on brain health and cognitive function. The rationale for its use in supporting memory and brain function is primarily based on the emerging concept of the "gut-brain axis," a bidirectional communication system between the gut microbiota and the central nervous system. Several preclinical studies in animal models suggest that supplementation with B. longum can improve anxiety-like behaviors, learning, and memory. For example, a 2016 study published in Translational Psychiatry showed that B. longum 1714 improved stress-related behaviors and cognitive performance in mice.

In humans, clinical evidence is still limited but growing. A small randomized, placebo-controlled trial (Allen et al., 2016) found that supplementation with B. longum 1714 in healthy volunteers led to reduced perceived stress and improved memory performance in certain cognitive tests. However, these studies are generally small, short-term, and often use specific strains, making it difficult to generalize the findings. There is not yet robust, large-scale clinical evidence to strongly support the use of B. longum for memory or brain function. Therefore, while there is some scientific validation for its potential, the overall quality and quantity of the evidence is still low (rated 2 out of 5).

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