Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Beta-hydroxybutyrate (BHB) is a ketone body produced during states of low carbohydrate availability, such as fasting or ketogenic dieting. There is growing scientific interest in BHB as a potential support for memory and brain function, particularly in the context of neurodegenerative diseases like Alzheimer's. Animal studies and some small-scale human trials suggest that BHB can provide an alternative energy substrate for neurons, which may be beneficial when glucose metabolism is impaired in the brain. For example, several studies have shown cognitive improvements in patients with mild cognitive impairment or Alzheimer's disease when provided with ketogenic diets or exogenous ketone supplements, which increase circulating BHB levels. Additionally, BHB has been observed to have anti-inflammatory and neuroprotective effects in preclinical models.

However, the evidence in humans is still limited and not yet conclusive. Most studies are small, short-term, or use surrogate markers rather than direct clinical outcomes. There is not yet robust, large-scale clinical trial evidence establishing BHB’s efficacy for enhancing memory or cognitive function in healthy individuals. Thus, while the use of BHB for brain health is grounded in plausible scientific mechanisms and early evidence, more rigorous research is needed before it can be widely recommended for memory and brain function support.

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